Trialling Covid-19 cures: Remdesivir mixed into drug cocktail – The Wall Street Journal

Scientists are working hard at unleashing the power of remdesivir, one of the great hopes for treating SARS-CoV-2, the virus that causes Covid-19, by combining it with other drugs in medical trials and testing different ways of administering it. Gilead's remdesivir was developed to treat Ebola – a virus that also appears to have jumped from animals, and quite possibly bats as may have been the case for Covid-19, to humans before spreading among people. The hunt for a preventative vaccine or cure for Covid-19 is a race against time, with many countries unable to lift lockdowns completely and restore normality until a vaccine or effective treatment is found. Remdesivir is just one of many therapies being tested. Others under investigation include drugs that have been used to treat malaria and autoimmune diseases and plasma transfusions from people who have recovered from Covid-19. The World Health Organisation has warned against relying on remedies that have not been tested by medical experts, after Madagascar's government announced the country has a herbal treatment for Covid-19. Reuters reports that African countries have been lining up for the tonic, based on the plant Artemisia annua which has anti-malarial properties. Madagascar has less than 200 confirmed cases of Covid-19 cases and no reported deaths, according to the Johns Hopkins Coronavirus Resource Center. – Jackie Cameron___STEADY_PAYWALL___.Gilead's remdesivir tested with other drugs to fight Covid-19.By Joseph Walker(The Wall Street Journal) – The promise and limitations of remdesivir, the first drug to prove capable of helping fight Covid-19, have kicked off efforts to see if it can work better in combination with other treatments and to create new, easier methods of administering it.Researchers are exploring whether the drug, made by Gilead Sciences can be combined with other antiviral treatments to make a more potent coronavirus-fighting cocktail.Six Covid-19 drug trials currently under way specify testing remdesivir with another medicine, according to Informa Pharma Intelligence. Another five trials are of drugs that would be given in tandem with whatever a hospital uses as standard treatment – which increasingly means remdesivir.Gilead is also studying new formulations of remdesivir so patients can take it outside of a hospital.Remdesivir, originally aimed at treating Ebola, has emerged as the go-to Covid-19 treatment. Federal health regulators quickly authorised its emergency use May 1, after it proved effective in a large, rigorously-designed study. Hospitals are lined up for doses.But the drug isn't a silver bullet. So far at least, it has shown to be only modestly effective in treating a sliver of very sick patients.Remdesivir's standard use in Covid-19 treatment "can be misleading because it suggests this is very, very good therapy, but it isn't," said Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases."It's standard because it's better than nothing," Dr. Fauci said.Development of HIV drugs in the 1980s proceeded on a similar path, with researchers in the 1980s building upon the early but limited success of the first agent to develop progressively better treatment regimens.In its key clinical trial, remdesivir shortened the recoveries of hospitalised patients by four days compared with a placebo. The seriously-ill patients still spent an average of 11 days in the hospital. NIAID supported the study.Moreover, the drug's use is limited to the hospital because it has to be administered with an intravenous infusion.A number of studies are under way exploring how to make remdesivir's impact stronger by pairing it with a separate drug that tamps down on the overactive immune response, known as a cytokine storm, triggered in some infected patients.Drug researchers want to see whether an arthritis drug, for example, can beat back the cytokine storm, while remdesivir stops the virus from replicating itself inside the lungs. Certain arthritis drugs reduce inflammation."That's the ideal situation for me, where you have combinations of drugs that are doing multiple jobs to holistically attack the disease," said Timothy Sheahan, assistant professor of epidemiology at the University of North Carolina, who has helped conduct laboratory tests of remdesivir in coronaviruses.Researchers conducting NIAID's trial of the drug are now testing it in combination with Eli Lilly & Co.'s arthritis therapy baricitinib, which is sold under the brand name Olumiant.A study evaluating arthritis drug Actemra, from Roche Holding AG 's Genentech unit, will include subjects taking remdesivir as part of their care, said Mark Eisner, a senior vice president at Genentech overseeing Actemra's clinical development.Researchers are unsure whether there will be enough supply of remdesivir to include it in all trials going forward, Dr. Eisner said. "It's a question that all of the clinical trial investigators have now," he said.Gilead, based in Foster City, Calif., is working on new ways to administer the drug outside of the hospital and whether it can be combined with other antivirals to make a more potent virus-killing cocktail.The company is developing an inhalation device so patients can suck the drug into their respiratory tracts. The company is also trying to make a pre-filled syringe that can be injected into the skin at home.If the new formulations pan out, they could be used to test remdesivir in patients who aren't in the hospital, Gilead Chief Medical Officer Merdad Parsey said last month.– Write to Joseph Walker at joseph.walker@wsj.com

Trialling Covid-19 cures: Remdesivir mixed into drug cocktail – The Wall Street Journal

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